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![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn9.mypornvid.fun/picture/preview/nUE0pUZ6Yl9mZF5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXR15HT9loyMcMP5zqJ-cK3tlAQN5v7P/(MyPornVid.fun)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
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_dress-yoga-legs-beginners-exercise-part3.webp "Beginner Yoga Poses for Legs<br/>Mountain Pose (Tadasana)<br/><br/>Stand with your feet together, arms by your sides.<br/>Distribute your weight evenly across both feet.<br/>Engage your thighs and lift your kneecaps.<br/>Lengthen through the spine and reach the crown of your head towards the ceiling.<br/>Hold for 30 seconds to 1 minute.<br/>Downward-Facing Dog (Adho Mukha Svanasana)<br/><br/>Start on your hands and knees.<br/>Tuck your toes and lift your hips towards the ceiling.<br/>Straighten your legs as much as possible without locking your knees.<br/>Press your heels towards the floor and hold for 1-3 minutes.<br/>Warrior I (Virabhadrasana I)<br/><br/>Stand with your feet wide apart.<br/>Turn your right foot out 90 degrees and your left foot in slightly.<br/>Bend your right knee over your right ankle.<br/>Raise your arms overhead, palms facing each other.<br/>Hold for 30 seconds to 1 minute, then switch sides.<br/>Warrior II (Virabhadrasana II)<br/><br/>From Warrior I, open your hips and shoulders to face the side.<br/>Extend your arms parallel to the floor, palms down.<br/>Look over your right hand.<br/>Hold for 30 seconds to 1 minute, then switch sides.<br/>Triangle Pose (Trikonasana)<br/><br/>Stand with your feet wide apart.<br/>Turn your right foot out 90 degrees and your left foot in slightly.<br/>Extend your arms out to the sides at shoulder height.<br/>Reach forward with your right hand and lower it to your shin or ankle.<br/>Extend your left arm towards the ceiling and look up.<br/>Hold for 30 seconds to 1 minute, then switch sides.<br/>Standing Forward Bend (Uttanasana)<br/><br/>Stand with your feet hip-width apart.<br/>Hinge at your hips and fold forward, keeping your spine long.<br/>Let your head hang and relax your neck.<br/>Hold for 1-2 minutes.<br/>Chair Pose (Utkatasana)<br/><br/>Stand with your feet together.<br/>Bend your knees and lower your hips as if you’re sitting back into a chair.<br/>Raise your arms overhead, palms facing each other.<br/>Hold for 30 seconds to 1 minute.<br/>What to Wear for Yoga<br/>Comfortable, Breathable Clothing:<br/><br/>Wear stretchy, form-fitting clothes that allow you to move freely.<br/>Avoid clothes that are too loose as they might get in the way of your poses.<br/>Yoga Pants or Leggings:<br/><br/>Choose high-waisted leggings or yoga pants that stay in place.<br/>Look for moisture-wicking fabric to keep you dry.<br/>Fitted Top:<br/><br/>Wear a fitted tank top or t-shirt that won’t ride up during poses.<br/>A sports bra with good support is essential for women.<br/>Bare Feet:<br/><br/>Practicing yoga barefoot helps with stability and balance.<br/>If you prefer, you can use yoga socks with grip.<br/>Optional Extras:<br/><br/>A light, breathable jacket or long-sleeve shirt for warm-up or cool-down.<br/>A headband or hair tie to keep hair out of your face.<br/>Tips for a Successful Yoga Practice<br/>Warm-Up: Spend a few minutes warming up to prepare your muscles for stretching.<br/>Listen to Your Body: Never push yourself into a pose. Move into each pose gently and stop if you feel pain.<br/>Breathe: Focus on your breath. Deep, steady breathing helps you relax and stay present.<br/>Stay Hydrated: Drink water before and after your practice.<br/>Practice Regularly: Consistency is key")
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